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Mpigi District is a rural district in Uganda with high maternal morbidity and mortality. While most pregnant women in Uganda attend antenatal clinics, few ultimately deliver their infants in a health facility. A review of maternal determinants and factors associated with health facility delivery is the focus of this study. This is a quantitative, descriptive, cross-sectional study of 257 women in the Mpigi District. The results show that women delivered in health facilities because they expected a safe delivery. Ten factors were found to be significantly associated with a higher possibility of health facility delivery: eight or more years of education (P=0.002); previous health facility delivery (P<0.0001); first delivery in a health facility (P...
Controlled drug delivery systems have been referred to as delayed action, extended action, gradual action, prolonged release, repeat action, sustained release, depot, timed release systems.This is one of the therapeutic systems of that used locally to obtain a constant drug concentration.Controlled drug delivery occurs when a polymer, whether natural or synthetic, is judiciously combined with a drug or other active agent in such a way that the active agent is released from the material in a predesigned manner.The release of the active agent may be constant over a long period, it may be cyclic over a long period, or it may be triggered by the environment or other external events.the purpose behind controlling the drug delivery is to achieve more effective therapies while eliminating the potential for both under- and overdosing.Other advantages of using controlled-delivery systems can include the maintenance of drug levels within a desired range, the need for fewer administrations,...
Target drug delivery system is a special form of drug delivery system where the pharmacologically active agent or medicament is selectively targeted or delivered only to its site of action or absorption and not to the non-target organs or tissues or cells. Targeted drug delivery implies for selective and effective localization of pharmacologically active moiety at pre identified (preselected) target in therapeutic concentration, while restricting its access to non-target normal cellular linings, thus minimizing toxic effects and maximizing therapeutic index. Targeting of drugs to special cells and tissues of the body without their becoming a part of systemic circulation is a very novel idea. If a drug can be administered in a form such that it reaches the receptor sites in sufficient concentration without disturbing in extraneous tissue cells. Targeted drug delivery is a method of delivering medication to a patient in a manner that increases the concentration of the medication in...
During the past three decades significant advances have been made in the area of the novel drug delivery. In a typical therapeutic regimen the drug dose and dosing interval are optimized to maintain drug concentration within the therapeutic window, thus ensuring efficacy while minimizing toxic effects. Survey indicated that dosing more than one or twice daily, greatly reduces patient compliance. So in recent year considerable attention has been focused on the development of novel drug delivery system and the main reason for this paradigm shift is relatively low development cost and time required for introducing a novel drug delivery system as compared to a new chemical entity. In the form of novel drug delivery system, an existing drug molecule can get a new life there by increasing its market value competitiveness and patent life among the various novel drug delivery system available in the market, per oral controlled release system hold the major market share because of their...
Local Drug Delivery System is an emerging trend in the field of Periodontology.Continues research is going-on and newer drugs are getting added as local drug delivery system.Eradicating microorganisms from the periodontal pocket is a crucial task in treating periodontitis. For treating periodontal diseases targeting of an anti-infective agent to infection sites with effective levels for a sufficient time while concurrently evoking minimal or no side effects is needed.Novel therapeutic agents are being improvised in the arena of local drug delivery system to ensure maximum benefit. This book will help both Under-graduate and Post-graduate students as well as the general practitioners in the field of dentistry to know the details about local drug delivery systems and local drug delivery agents being used for periodontal diseases and other oral infections in detail.
Floating drug delivery system or hydrodynamically balance systems have a bulk density lower than gastric fluid and thus remains buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. While the system is floating on gastric contents the drug is released slowly at a desired rate from the system. After the release of drug residual system is emptied from the stomach. This results in increase in gastric residence time and a better control of fluctuation in plasma drug concentration. Development of oral controlled-release systems has been a challenge to formulation scientists because of their inability to restrain and localize the system in the targeted area of the gastrointestinal tract.